What is the treatment for cardiotoxicity?

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What is the treatment for cardiotoxicity?

The most common medications used for cardiotoxicity treatment include: Beta-blockers, which slow down a patient’s heart rate, lower a patient’s blood pressure and strengthen the heart muscle can reduce palpitations and arrhythmias, hypertension and heart failure.

How do you stop cardiotoxicity?

Dexrazoxane cardioprotection. Dexrazoxane is the only FDA- approved drug for preventing anthracycline-induced cardiotoxicity [46]. In August 2014, the FDA designated dexrazoxane as an orphan drug for “prevention of cardiomyopathy for children and adolescents 0 through 16 years of age treated with anthracyclines” [47].2019-12-02

What causes cardiotoxicity?

Cancer drugs and treatments can cause direct damage to the heart. This is known as cardiotoxicity. In the past, patients were focused on recovering from cancer, but today, with the increase in cancer survivorship, the incidence of heart issues associated with chemotherapy and radiation has increased.

What are cardiovascular toxins?

Cardiovascular toxicity includes damage to the heart due to toxin-induced electrophysiological abnormalities or/and muscle damage, as well as vascular atherosclerosis due to oxidative stress and inflammation. Taken together, these abnormalities may impair blood flow and circulation.

How do you know if you have cardiotoxicity?

Symptoms: You may be overly tired, or very weak (fatigued). It may be hard for you to do any kind of your normal activities. You may have “coughing spells”, or a long-term (chronic) cough, if your cardiotoxicity results in heart failure (such as congestive heart failure).

How is cardiotoxicity diagnosed?

Standard current methods for detection of cardiotoxicity primarily involve serial measurement of the left ventricular ejection fraction (LVEF), a parameter that when reduced is a late manifestation in the cardiotoxic paradigm and when the possibility for reversibility declines.2018-06-11

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What can lead to cardiotoxicity?

Cardiotoxicity can develop during cancer treatment – or – can occur within days or months or years after cancer treatment, once patients are cancer-free. Heart damage caused by chemotherapy-induced cardiotoxicity can reduce quality of life and increase the risk of death from cardiac-related causes.2019-05-10

How common is cardiotoxicity?

Cardiotoxicity is reported in 7% to 28% of patients receiving a regimen containing cyclophosphamide.2017-09-15

Does doxorubicin cause cardiotoxicity?

Doxorubicin is a highly effective anticancer agent but causes cardiotoxicity in many patients. The mechanisms of doxorubicin-induced cardiotoxicity remain incompletely understood.2017-03-16

What drug can lead to cardiotoxicity?

Cytostatic antibiotics of the anthracycline class are the best known of the chemotherapeutic agents that cause cardiotoxicity. Alkylating agents such as cyclophosphamide, ifosfamide, cisplatin, carmustine, busulfan, chlormethine and mitomycin have also been associated with cardiotoxicity.

What is the main cause of cardiomyopathy?

Viral infections in the heart are a major cause of cardiomyopathy. In some cases, another disease or its treatment causes cardiomyopathy. This might include complex congenital (present at birth) heart disease, nutritional deficiencies, uncontrollable, fast heart rhythms, or certain types of chemotherapy for cancer.

What is a cardiotoxic?

Cardiotoxicity is a condition when there is damage to the heart muscle. As a result of cardiotoxicity, your heart may not be able to pump blood throughout your body as well. This may be due to chemotherapy drugs, or other medications you may be taking to control your disease.

Can cardiotoxicity be reversed?

With the exception of anthracyclines, cardiotoxicity from most targeting agents is reversible. Concomitant use of cardiotoxic drugs should be avoided, and early detection of asymptomatic cardiac dysfunction is important.2017-09-15

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Why does doxorubicin cause cardiotoxicity?

Doxorubicin induces cardiotoxicity through upregulation of death receptors mediated apoptosis in cardiomyocytes.2017-03-16

Is cardiotoxicity heart failure?

Heart failure is one of the most dramatic clinical expressions of cardiotoxicity, and it may occur acutely or appear years after treatment.2019-05-24

Which drug metabolite causes cardiotoxicity?

Doxorubicin (former generic name, adriamycin), a highly effective anticancer drug, produces cardiotoxicity, which limits its therapeutic potential.

Is doxorubicin toxic to the heart?

It is well recognized that doxorubicin may cause damage to the heart in some individuals. While other anthracyclines (like epirubicin and mitoxantrone) may also cause heart damage, the chances are more common with doxorubicin. Doxorubicin causes both early and late heart damage (also called cardiotoxicity).2020-06-30

What causes cardiac toxicity?

What is cardiac toxicity? Cardiac (heart) toxicity is a side effect of cancer treatment that leads to damage to the heart muscle or valves. Both chemotherapy and radiation can contribute to cardiac toxicity, depending on the type of medication(s) used and where radiation treatment was given.

How do you monitor cardiotoxicity?

Targeted molecular imaging with SPECT, PET, or MRI may be able to detect cell death due to doxorubicin25 and to detect subclinical cardiotoxicity.

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